Case Files
Teasers & Deleted Scenes
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Date: Thu, 30 Aug 2007 07:03:32 -0700
From: SSA Stephen Reyes
To: SA Charles Villette
Subject: Cytosolic PEPCK-C in skeletal musculature of transgenic mice
Please read. What do you think?
--Reyes
Attachment: J Biol Chem. 2007 Aug 23.
Over-expression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse.
http://www.jbc.org/content/early/2007/08/23/jbc.M706127200.full.pdf+html
Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH.
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Date: Thu, 30 Aug 2007 07:24:05 -0700
From: SA Charles Villette
To: SSA Stephen Reyes
Subject: Re: Cytosolic PEPCK-C in skeletal musculature of transgenic mice
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SSA Reyes,
I think it's pretty dramatic research. You want a muscle biopsy, I take it?
Even if proves a partial explanation for gamma physical capabilities and increased aggression levels--well, we know it doesn't translate directly from the micro to the macro, so to speak.
Especially with regard to the enhanced lifespan. And it doesn't make sense of the enhanced carbohydrate demand--or the fact that a gamma's caloric need is more like 250% than 160% of a baseline. That's still got to be brain glucose usage--or that's our best hypothesis.
But it's a fascinating possibility, and it would certainly explain some things.
I wonder how these mice stand up to trauma.
--Chaz Villette
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Date: Tue, 4 Sept 2007 04:15:35 -0700
From: Madeline Frost, M.D.
To: SSA Stephen Reyes
Subject: Biopsy results
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Dr. Reyes,
I am writing to inform you that the hospital lab reports significantly higher than normal PEPCK-C activity levels in the samples tested. Average levels of 11.3 units/g tend to support your hypothesis.
Full results to follow under separate cover.
sincerely,
M. Frost
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Date: Tue, 28 Sep 2009 12:15:04 -0700
From: SA Charles Villette
To: SSA Stephen Reyes
Subject: DNA results vs. mighty mice
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Reyes--
I've been thinking about the recent DNA and FMRI results in light of our 2007 findings regarding PEPCK activity levels in jammers. Specifically, it's becoming increasingly obvious that the anomaly has teratogenic, hormonal, molecular, and cellular-level effects in addition to the cognitive and metabolic ones--but apparently not genetic ones, at least not in the primary host. (The primary host's offspring, as we have seen, are a different matter.)
What I find particularly interesting is the ability of the anomaly to affect cellular metabolism/mitochondrial proliferation apparently without altering the host's DNA.
Even though we haven't identified the causative agent, it's conforming more and more to the disease or parasite model (since infectious disease is a form of parasitism, I don't think they're exclusive).
It's an extremely complex disease, in other words, but it's a disease, and one we can address proactively as we come to understand it better.
As you have been insisting all along.
With that in mind, Dr. Ramachandran, Dr. Allison, and myself would like to propose a treatment program. Attached please find the transcript of a meeting carried out at Idlewood last week, along with a tentative course of therapy.
Eddie Cieslewicz and his guardian have agreed to participate in a small-scale pilot. We'd like your input on this before we proceed.
--Chaz
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Date: Tue, 28 Sep 2009 13:35:21 -0700
From: SSA Stephen Reyes
To: SA Charles Villette
Subject: Re: DNA results vs. mighty mice
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Go for it.
SR
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